Fully substituted selenomethionyl protein was produced by growth and induction of these cells in a synthetic medium containing selenomethionine together with the other 19 amino-acids.

It is mixed into the tobacco along with glycerine and flavorings; sometimes it is used along with honey and other syrups or fully substituted by them.

In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI.

In animal studies it fully substituted for salvinorin A and the synthetic kappa agonist U-69593, and was active at doses as low as 0.005 mg/kg.

After the end of the monarchy the orders and the medals of the Kingdom of Bulgaria were fully substituted with other ones.

To displace nitrogen without the increased oxygen concentration, other diluent gases can be used, usually helium, when the resultant three gas mixture is called trimix, and when the nitrogen is fully substituted by helium, heliox.

In drug discrimination tests on animals, it fully substituted for both DOM and 5-MeO-DMT.

Specialisation : children, neighbours, friends and other relatives performed different if overlapping roles which could not be fully substituted for each other.