There is evidence that Hope has been extremely significant in the region throughout its long history.

This trend, although slight, is extremely significant because of the large sample used.

I should be able to create an extremely significant storm for you.

All these factors make everything she says extremely significant.

"It's an extremely significant number," he said of the price, "though nothing like this has been on the market in years."

It is an extremely significant body of water in a geopolitical sense.

A more complex, and extremely significant, question the study also asked was: "How do these young people come to end up in custody?"

An extremely significant question about the future is handled in paragraphs 6 and 7.

This could be extremely significant in showing the path we are to go down.

But in actuality it could be an extremely significant event.