The DD mediates self-association of these receptors, thus giving the signal to downstream events that lead to apoptosis.

This transformation helps trigger downstream events to repair the damaged DNA.

However, it is still unclear if macro vascular pathology is a primary feature of SSc or an indirect effect of some of the downstream events related to this disease.

The Jak-Stat1 pathway was intact in these cells, indicating that downstream transcriptional events are involved in the inhibition.

Chromatin-binding assays of Cdc45 in yeast and Xenopus have shown that a downstream event of CDK action is loading of Cdc45 onto chromatin.

Yet, in a chain of computation, downstream events may very well find some types of results from earlier resolutions of ramification as problematic for their own algorithms.

The use of dsRNAi helps to refine the nature of such interactions and their effects on downstream events in the signaling circuitry.

Thus, while modafinil's unique stimulant profile features interactions with monoamine systems, these may very well be downstream events secondary to effects on specific, electrotonically-coupled populations of GABAergic interneurons.

AP1 is a transcription factor that binds to DNA and in downstream events promotes cell proliferation.

Retinoids can also affect cellular responsiveness to TGF-βs at the level of receptor expression and downstream events [ 37, 38].