"When you're regulating activity this far upstream," he said, "you have to be careful of downstream effects."

The downstream effects of this proposed dam will be far worse than the effects in the dam footprint.

AT&T may not have anticipated the downstream effects of iPhone customers' high data usage.

Several studies have focused on the downstream effects of endostatin reception.

The downstream effects of technologies nuclear power, genetically modified food and mobile phones may not be well understood.

"It's like a cascade of related downstream effects, and all of them have to be considered," she told me at the end of a long September day.

The downstream effect of the dam will be to delay the arrival of the annual flood and to reduce its intensity.

An important downstream effect of trastuzumab binding to HER2 is an increase in p27, a protein that halts cell proliferation.

We can consider the downstream effects when something happens upstream.