As the story goes, she was in a period of deep despair.

Paul remains in deep despair over his mother's death.

Jerome must have been in such deep despair over the collapse of his career that by then he could no longer face them.

Your idea of a cure might only drive her into deeper despair.

It was touching despair, so deep that she could not cope.

A straggling few got up to go in deep despair.

I find myself doing this to keep from sinking into a deep despair.

With a feeling of deep despair she realized there was no escape.

The devastation is immense and the people are in deep despair.

In deep despair, he thinks of better days, and writes a song, Home!