Inhibition of CYP17 activity thus decreases circulating levels of testosterone.

Females had abnormal locomotor coordination, caudal vertebral transformation, decreased circulating amylase levels and increased mean platelet volume.

The remaining tests were carried out on heterozygous mutant adult mice and decreased circulating triglyceride levels were observed in female animals, while males displayed abnormal behaviour in an open field.

Further studies have shown that a reduction of sleep duration to 4 hours for two consecutive nights has recently been shown to decrease circulating leptin levels and to increase ghrelin levels, as well as self-reported hunger.

Homozygous mutant adults of both sexes had a decreased body weight as determined by DEXA, displayed vertebral fusion and had clinical chemistry abnormalities including hypoalbuminemia and decreased circulating fructosamine levels.

Females also had decreased body weight, decreased circulating HDL cholesterol levels, and increased susceptibility to bacterial infection.

One is that nicotine might decrease circulating insulin levels, which would be consistent with less craving for sweets among smokers.

Males additionally displayed decreased circulating glucose and increased circulating bilirubin levels.

The remaining tests were carried out on heterozygous mutant adult mice and decreased circulating amylase levels were observed in male animals.

PCSK9 antisense oligonucleotide from Isis Pharmaceuticals has been shown to increase expression of the LDLR and decrease circulating total cholesterol levels in mice.