The autophosphorylated form of this enzyme does not require Ca 2+ and as a result becomes constitutively active.

Crenolanib inhibits both wild type FLT3 and its constitutively active mutations.

A mutation that causes certain tyrosine kinases to be constitutively active has been associated with several cancers.

In achondroplasia, the mutated form of the receptor is constitutively active and this leads to severely shortened bones.

It is a constitutively active ion-channel.

Other mutant forms can result in a protein that is abnormally regulated and constitutively active ('on' all the time).

In cell biology, a constitutively active protein is a protein whose activity is constant and active.

However, PDPK1 is believed to be constitutively active and does not always require phosphatidylinositols for its activities.

The proteins is made to be constitutively active using recombinant techniques.

STAT3 can promote oncogenesis by being constitutively active through various pathways as mentioned elsewhere.