The increased conformational flexibility of L703766 may also explain the weakened interaction with the receptor.

The interface for the database allows researchers to find proteins with a range of conformational flexibility allowing them to find highly flexible proteins for example.

Furthermore, the conformational flexibility of NS5A plays an important role in multiple HCV infection stages.

The conformational flexibility of larger rings potentially allows for a combination of acyclic and macrocyclic stereocontrol to direct reactions.

This theme of conformational flexibility, particularly with regard to the C-terminal domain of these enzymes, has been observed in multiple proteins in the superfamily.

Limited conformational flexibility can also be realized within a continuum electrostatics approach, e.g., for considering multiple aminoacid sidechain rotamers.

In addition, the ring structures of cyclopropanes/enes and cyclclobutanes/enes offer very little conformational flexibility.

The conformational flexibility of GABA is important for its biological function, as it has been found to bind to different receptors with different conformations.

The data is consistent with the formation of biradical species on a relatively flat potential energy surface allowing for restricted conformational flexibility before the products are formed.

The amount of conformational flexibility and therefore conformational evolution accessible to the diradical species before forming product depends on the constitution of the potential energy surface.