Patients who are taking other treatments for their symptoms (e.g. beta blockers and nifedipine) have developed minor transient conduction defects when given Prajmaline.

The drug should therefore not be given to patients with cardiac conduction defects and should not be combined with mefloquine.

In 24 children with inherited disorders of fatty acid oxidation, conduction defects or arrhythmias were the predominant presenting feature [ 14 ] .

Cardiac involvement occurs in 91% of patients, including cardiomegaly (up to dilated cardiomyopathy), symmetrical hypertrophy, heart murmurs, and conduction defects.

This affects in the cells action potential profile, as seen in cardiomyocytes, pneumocytes and neurons leading to conduction defects.

Typical findings are those of an enlarged heart with non specific conduction defects.

In many cases, these heart problems stem from abnormalities of the electrical signals that control the heartbeat (cardiac conduction defects) and abnormal heart rhythms (arrhythmias).

Intraventricular conduction defects and bundle branch block, especially left bundle branch block, are also common.

A weakening of the heart muscle (cardiomyopathy) is common and may manifest as arrhythmia, conduction defects or congestive heart failure.

Persons at greatest risk are those with preexisting cardiac conduction defects and those who have taken an overdose.