At the same time, the new systems will have a big effect on the American work force.

The years in Europe had a big effect on him.

This problem has a big effect on the left half of the brain.

We all know friends are important, but strong social ties can also have a big effect on your health.

They say that changes to the system would probably have a big effect on health spending starting in five or 10 years.

It was to have a big effect on my whole life.

That had a big effect on the structure of human society.

That neighborhood culture had such a big effect on you.

This would have a big effect on their later lives.

Even small changes can have big effects on your stress level.