We must then obtain the contribution of additional compensatory mutations at distance d + 1.

In synergystic epistasis, each additional mutation has increasing negative impact on fitness.

As some randomly acquire additional mutations, they grow even more.

The discovery of additional deep rooting mutations in known lineages could lead to a rearrangement of the family tree.

Two additional mutations, Arg356Ala and Arg356Glu, were prepared to further elucidate the role of Arg356.

Sequencing is used to ensure the correct mutation has been generated without additional mutations.

This instability is caused by additional mutations.

All mutant clones were fully re-sequenced bidirectionally to ensure that no additional mutations were introduced.

In the present study we made additional mutations.

These error-prone polymerases are thought to introduce additional mutations randomly across the DNA gap.