make a difference , also: make the difference

In fact, nothing I've tried as yet has made very much difference at all.

Nor 218 would the knowledge have made much difference to him.

The answer seems to be making little difference these days.

If he would agree to what happened today, then anything I could say will probably make little difference to him.

But many students came to the school too recently for its services to make much difference.

And the name of the college also makes little difference in the long run.

"A few years make little difference in how close I can come to you."

"Why should where the money came from make so much difference?"

No one is sure how much difference the drug makes.

A few weeks or months more shouldn't make much difference to him.