hit the road informal
hit the trail informal

We got a late start and didn't hit the trail until around noon.

I'll write the letter now an' then you hit the trail.

We're going to hit the trail again, and head due east.

Then we wait for zero hour and hit the trail.

Soon the rescue party was ready to hit the trail.

It was still early afternoon outside when we hit the trail.

Right now I'd better stop talking and hit the trail.

"We should be able to get our outfit together and hit the trail in a couple days."

I guess we can be thinking about hitting the trail for home pretty soon now.

Check out these training tips before you hit the trail.