The change at Avis, the second-largest rental company in the country, goes in two directions.

The deal is thought to be the second-largest between a big pharmaceutical company and a biotechnology company for a single product.

Harcourt is the second-largest company in online training, behind Smart Force.

Reynolds is the second-largest company, with about a third of the domestic market.

Glaxo Wellcome is the second-largest pharmaceutical company on the planet.

Now Avis, the second-largest company in the market, is planning its own public debut.

By 1954, Avis was the second-largest company in the industry, behind only Hertz.

Ford is the nation's second-largest company in sales after G.M.

Although Vanguard is the second-largest company in the business, it hasn't grown much over the last few years.

The Vanguard Group, the second-largest company, was sixth with a loss of 7.6 percent.